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Monday 31/10
KEMM35, KEMM76-77, Introduction meeting, Compulsory, KC:B
10:00
09:15
KEMM35, Introduction, KC:E (M:D), Derek Logan, Welcome & short overview of course content
12:00
10:00
KEMM35, Lecture, KC:L, Derek Logan, Integrated structural biology: an introduction
15:00
13:15
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Tuesday 1/11
KEMM35, Lecture, KC:M, Ingemar André, Overview of protein structure, sequence-structure relationships
12:00
10:15
KEMM35, Lecture, KC:D (M:E), Ingemar André, The thermodynamic driving forces for protein folding
15:00
13:15
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Wednesday 2/11
KEMM35, Exercise, Bioinformatics computer room, floor -1, Introduction to PyMOL
12:00
10:15
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Thursday 3/11
KEMM35, Lecture, KC:F, Ingemar André, Protein folds and databases
12:00
10:15
KEMM35, Exercise, Bioinformatics computer room, floor -1, Course assistants, Protein databases
16:00
13:15
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Friday 4/11
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Sunday 6/11
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Monday 7/11
KEMM35, Lecture, KC:M, Ingemar André, Sequence-based bioinformatical methods
12:00
10:15
KEMM35, Exercise, Bioinformatics computer room, floor -1, Course assistants, Sequence searching
15:00
13:15
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Tuesday 8/11
KEMM35, Lecture, KC:S, Ingemar André, Structure prediction, AlphaFold, protein-protein complexes
12:00
10:15
KEMM35, Exercise, Bioinformatics computer room, floor -1, Course assistants, Structure prediction with AlphaFold
16:00
13:15
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Wednesday 9/11
KEMM35, Exercise, Bioinformatics computer room, floor -1, Course assistants, Protein-protein docking (EvoDOCK, ± XL-MS), part 1
16:00
13:15
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Thursday 10/11
KEMM35, Exercise, Bioinformatics computer room, floor -1, Course assistants, Protein-protein docking (EvoDOCK, ± XL-MS), part 2
16:00
13:15
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Friday 11/11
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Saturday 12/11
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Sunday 13/11
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Monday 14/11
KEMM35, Lecture, KC:M, Susanna Horsefield, Crystallography Ia: Protein crystallisation
12:00
10:15
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Tuesday 15/11
KEMM35, Lecture, KC:D (M:E), Susanna Horsefield, Crystallogr. Ib: Membrane proteins: structure and crystallisation
15:00
13:15
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Wednesday 16/11
KEMM35, Lecture, KC:F, Derek Logan, Crystallography II: Crystals and symmetry
12:00
10:15
KEMM35, Lecture, KC:F, Derek Logan, Crystallography III: Waves, Fourier transforms and diffraction
17:00
14:15
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Thursday 17/11
KEMM35, Laboratory session, KC:GU-labb 2, Course assistants, Exercise I: Crystallisation (groups 1+2)
12:00
09:00
KEMM35, Laboratory session, KC:GU-labb 2, Course assistants, Exercise I: Crystallisation (groups 3+4)
16:00
13:00
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Friday 18/11
KEMM35, Lecture, KC:D (M:E), Derek Logan, Crystallography IV: X-ray data collection
12:00
10:15
KEMM35, Exercise, Bioinformatics computer room, floor -1, Course assistants, Exercise II: Crystal packing analysis
15:00
13:15
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Saturday 19/11
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Sunday 20/11
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Monday 21/11
KEMM35, Lecture, KC:E (M:D), Derek Logan, Crystallography V: The phase problem: experimental phasing
12:00
10:15
KEMM35, Exercise, Bioinformatics computer room, floor -1, Derek Logan, Course assistants, Exercise III: Bragg's law and the Fourier transform
16:00
13:15
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Tuesday 22/11
KEMM35, Lecture, KC:F, Derek Logan, Crystallography VI: The phase problem: molecular replacement
12:00
10:15
KEMM35, Exercise, Bioinformatics computer room, floor -1, Course assistants, Exercise IIIb: Coot and the Electron Density Server (EDS)
16:00
13:15
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Wednesday 23/11
KEMM35, Study visit, Site visit LP3, Maria Gourdon (LP3), Robotic crystallisation demo (groups 1 and 2)
12:00
09:00
KEMM35, Study visit, Site visit LP3, Maria Gourdon (LP3), Robotic crystallisation demo (groups 3 and 4)
16:00
13:00
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Thursday 24/11
KEMM35, Exercise, Bioinformatics computer room, floor -1, Derek Logan, Course assistants, Exercise IV: Diffraction data processing
16:00
13:15
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Friday 25/11
KEMM35, Questions and Answers, KC:D (M:E), Derek Logan, Ingemar André, Q&A on the course so far
12:00
10:15
KEMM35, Exercise, LP3, Inspect and document crystals from Exercise I (first group(s))
16:00
13:15
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Saturday 26/11
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Sunday 27/11
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Monday 28/11
KEMM35, Exercise, Bioinformatics computer room, floor -1, Derek Logan, Course assistants, Exercise V: Phase problem
16:00
13:15
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Tuesday 29/11
KEMM35, Exercise, Bioinformatics computer room, floor -1, Derek Logan, Course assistants, Exercise VI: Molecular replacement
12:00
10:15
KEMM35, Exercise, Bioinformatics computer room, floor -1, Derek Logan, Course assistants, Exercise VI: Molecular replacement
16:00
13:15
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Wednesday 30/11
KEMM35, Lecture, DC:Lilla hörsalen, Derek Logan, Crystallography VII: Electron density and model building
12:00
10:15
KEMM35, Exercise, LP3, Inspect and document crystals from Exercise I (second group(s))
16:00
13:15
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Thursday 1/12
KEMM35, Lecture, KC:G, Derek Logan, Crystallography VIII: Refinement and validation
12:00
10:15
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Friday 2/12
KEMM35, Exercise, MAX IV Laboratory, Brunnshög, Derek Logan, Ana Gonzalez (MAX IV), Data collection tutorial at BioMAX beamline (groups 1+2)
12:00
08:00
KEMM35, Exercise, MAX IV Laboratory, Brunnshög, Derek Logan, Ana Gonzalez (MAX IV), Data collection tutorial at BioMAX beamline (groups 3+4)
17:00
13:00
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Saturday 3/12
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Sunday 4/12
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Monday 5/12
KEMM35, Exercise, Bioinformatics computer room, floor -1, Course assistants, Exercise VII: Model building
12:00
10:15
KEMM35, Exercise, Bioinformatics computer room, floor -1, Course assistants, Exercise VII: Model building
15:00
13:15
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Tuesday 6/12
KEMM35, Lecture, KC:E (M:D), Derek Logan, Small-angle X-ray scattering (SAXS)
12:00
10:15
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Wednesday 7/12
KEMM35, Lecture, Bioinformatics computer room, floor -1, Course assistants, SAXS data processing tutorial
12:00
09:15
KEMM35, Lecture, KC:E (M:D), Kristofer Modig, Applications of NMR in structural biology
15:00
13:15
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Thursday 8/12
KEMM35, Lecture, KC:G, Esko Oksanen (ESS), Neutron scattering and neutron diffraction
12:00
10:15
KEMM35, Exercise, Bioinformatics computer room, floor -1, Esko Oksanen (ESS), Neutron crystallography tutorial
16:00
13:15
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Friday 9/12
KEMM35, Study visit, Esko Oksanen (ESS), Visit to ESS
11:00
09:00
KEMM35, Study visit, Esko Oksanen (ESS), Visit to ESS
15:00
13:00
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Saturday 10/12
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Sunday 11/12
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Monday 12/12
KEMM35, Lecture, KC:M, Derek Logan, Cryo-electron microscopy: principles
12:00
10:15
KEMM35, Exercise, Bioinformatics computer room, floor -1, Course assistants, ChimeraX - getting started
16:00
13:15
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Tuesday 13/12
KEMM35, Lecture, KC:B, Anu Tyagi, Cryo-electron microscopy: sample preparation
12:00
10:15
KEMM35, Exercise, nCHREM, Building V, Kemicentrum, Anu Tyagi, Exercise: sample preparation
16:00
13:15
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Wednesday 14/12
KEMM35, Lecture, DC:Lilla hörsalen, Anu Tyagi, Cryo-electron microscopy: data collection
12:00
10:15
KEMM35, Exercise, nCHREM, Building V, Kemicentrum, Crispin Hetherington, Anu Tyagi, Exercise/demo
16:00
13:15
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Thursday 15/12
KEMM35, Lecture, KC:M, Derek Logan, Anu Tyagi, Cryo-electron microscopy: data analysis
12:00
10:15
KEMM35, Exercise, Bioinformatics computer room, floor -1, Derek Logan, Anu Tyagi, Exercise: data analysis
16:00
13:15
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Friday 16/12
KEMM35, Lecture, DC:Lilla hörsalen, Derek Logan, Cryo-electron microscopy: model building
12:00
10:15
KEMM35, Exercise, Bioinformatics computer room, floor -1, Derek Logan, Exercise: model building
16:00
13:15
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Saturday 17/12
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Sunday 18/12
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Monday 19/12
KEMM35, Questions and Answers, Bioinformatics computer room, floor -1, Derek Logan, Pre-holidays Q&A session
15:00
13:15
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Monday 9/1
KEMM35, Questions and Answers, KC:F, Derek Logan, Final Q&A, course evaluation
15:00
13:15
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Tuesday 10/1
KEMM35, Self-study, FREE FOR STUDY
17:00
08:00
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Wednesday 11/1
KEMM35, Self-study, FREE FOR STUDY
17:00
08:00
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Thursday 12/1
KEMM35, Self-study, FREE FOR STUDY
17:00
08:00
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Friday 13/1
KEMM25, KEMM35, Structural Biochemistry, Written exam, Examination, KC:H-I
19:00
14:00
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KEMM25, KEMM35, Structural Biochemistry, Written exam, Retake examination, KC:L
13:00
08:00
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