Time |
Activity, Description, Mandatory |
Other Information, Comment |
Course, Room, Place, URL |
Lecturer, Teacher |
Tentamenslänk |
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| w3 | Mon 15/1 w3 | ||||||||||||||||||||||||||||
| 09:00 - 09:15 | Introduction | Welcome and introduction to the course |
4TX030 Rolf Bergin, https://medarbetare.ki.se/larosal-rolf-bergin |
Pernilla Stridh, Narsis Kiani | |||||||||||||||||||||||||
| 09:15 - 10:00 | Lecture | Sampling schemes, statistical inference, types of data |
4TX030 Rolf Bergin, https://medarbetare.ki.se/larosal-rolf-bergin |
Pernilla Stridh, Narsis Kiani | |||||||||||||||||||||||||
| 10:15 - 12:00 | Lecture | Descriptive statistics, summary measures, graphs |
4TX030 Rolf Bergin, https://medarbetare.ki.se/larosal-rolf-bergin |
Pernilla Stridh, Narsis Kiani | |||||||||||||||||||||||||
| 13:00 - 16:00 |
Workshop Mandatory |
Computer lab session Please bring your laptop and charger. |
4TX030 Rolf Bergin, https://medarbetare.ki.se/larosal-rolf-bergin |
Pernilla Stridh, Narsis Kiani | |||||||||||||||||||||||||
| Tue 16/1 | |||||||||||||||||||||||||||||
| 09:00 - 10:00 | Lecture | Hypothesis testing, distributions |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Pernilla Stridh, Narsis Kiani | |||||||||||||||||||||||||
| 10:15 - 12:00 | Lecture | Simple parametric and non-parametric tests |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Pernilla Stridh, Narsis Kiani | |||||||||||||||||||||||||
| 13:00 - 16:00 |
Workshop Mandatory |
Computer lab session |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Pernilla Stridh, Narsis Kiani | |||||||||||||||||||||||||
| Wed 17/1 | |||||||||||||||||||||||||||||
| 09:00 - 10:00 | Lecture | Paired tests and correlations |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Pernilla Stridh, Narsis Kiani | |||||||||||||||||||||||||
| 10:15 - 12:00 | Lecture | Critical reading and group discussion |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Pernilla Stridh, Narsis Kiani | |||||||||||||||||||||||||
| 13:00 - 16:00 |
Workshop Mandatory |
Computer lab session |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Pernilla Stridh, Narsis Kiani | |||||||||||||||||||||||||
| Thu 18/1 | |||||||||||||||||||||||||||||
| 09:00 - 12:00 | Lecture | Questions and answers, overview of the labs (optional) |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Pernilla Stridh, Narsis Kiani | |||||||||||||||||||||||||
| 13:00 - 16:00 | Self-study | Preparation for exam |
4TX030 Optional location |
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| Fri 19/1 | |||||||||||||||||||||||||||||
| 09:00 - 14:00 | Self-study | Preparation for exam |
4TX030 Optional location |
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| w7 | Mon 12/2 w7 | ||||||||||||||||||||||||||||
| 09:30 - 12:00 |
Introduction Mandatory |
Course introduction and Lab Safety |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Kristian Dreij Hanna Karlsson |
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| 13:00 - 16:00 |
Laboratory session Mandatory |
Lab week 1 Lab: Cytotoxicity, Groups 1-5. Self studies, Group 6-10. See detailed schedule |
4TX030 Lab at IMM |
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| Tue 13/2 | |||||||||||||||||||||||||||||
| 09:00 - 12:00 | Self-study |
4TX030 Optional location |
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| 13:00 - 16:00 |
Laboratory session Mandatory |
Lab: Cytotoxicity, Groups 1-5. Journal Club #1, Groups 6-10. See detailed schedule |
4TX030 218, https://medarbetare.ki.se/218 |
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| Wed 14/2 | |||||||||||||||||||||||||||||
| 09:00 - 16:00 | Sports day |
4TX030 Optional location |
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| Thu 15/2 | |||||||||||||||||||||||||||||
| 09:00 - 12:00 |
Laboratory session Mandatory |
Lab: Cytotoxicity, Groups 6-10. Self studies, Group 1-5. See detailed schedule |
4TX030 Lab at IMM |
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| 13:00 - 16:00 |
Seminar Mandatory |
Journal Club #1, Groups 1-5. See detailed schedule. |
4TX030 218, https://medarbetare.ki.se/218 |
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| Fri 16/2 | |||||||||||||||||||||||||||||
| 09:00 - 12:00 |
Laboratory session Mandatory |
Lab: Cytotoxicity, Groups 6-10. See detailed schedule |
4TX030 Lab at IMM |
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| 13:00 - 16:00 | Self-study | Preparation for Omics course. |
4TX030 Optional location |
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| w8 | Mon 19/2 w8 | ||||||||||||||||||||||||||||
| 09:30 - 10:00 |
Introduction Mandatory |
Introduction - bioinformatics module |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Anda Gliga, Pekka Kohonen | |||||||||||||||||||||||||
| 10:00 - 12:00 |
Lecture Mandatory |
Transcriptomics in toxicology |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Anda Gliga | |||||||||||||||||||||||||
| 13:00 - 14:00 | Lecture | Metabolomics |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Antonio Checa | |||||||||||||||||||||||||
| 14:00 - 16:00 |
Study visit Mandatory |
Visit metabolomics facility - Biomedicum |
4TX030 Biomedicum |
Antonio Checa | |||||||||||||||||||||||||
| Tue 20/2 | |||||||||||||||||||||||||||||
| 09:00 - 10:00 |
Introduction Mandatory |
Downstream analysis - walk through |
4TX030 Ada Lovelace, https://medarbetare.ki.se/ada-lovelace |
Anda Gliga | |||||||||||||||||||||||||
| 10:00 - 12:00 |
Group work Mandatory |
Group work - bioinformatic analysis |
4TX030 Ada Lovelace, https://medarbetare.ki.se/ada-lovelace |
Pekka Kohonen | |||||||||||||||||||||||||
| 13:00 - 16:00 |
Group work Mandatory |
Group work - bioinformatic analysis |
4TX030 Ada Lovelace, https://medarbetare.ki.se/ada-lovelace |
Pekka Kohonen | |||||||||||||||||||||||||
| Wed 21/2 | |||||||||||||||||||||||||||||
| 09:00 - 12:00 |
Group work Mandatory |
Group work - bioinformatic analysis |
4TX030 Ada Lovelace, https://medarbetare.ki.se/ada-lovelace |
Pekka Kohonen | |||||||||||||||||||||||||
| 13:00 - 16:00 |
Group work Mandatory |
Group work - bioinformatic analysis |
4TX030 Ada Lovelace, https://medarbetare.ki.se/ada-lovelace |
Pekka Kohonen | |||||||||||||||||||||||||
| Thu 22/2 | |||||||||||||||||||||||||||||
| 09:00 - 10:30 | Lecture |
Proteomics (Lecture in Zoom.) |
4TX030 Optional location https://ki-se.zoom.us/j/65343152262 |
Amirata Saei Dibavar | |||||||||||||||||||||||||
| 10:30 - 12:00 | Self-study |
4TX030 Optional location |
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| 13:00 - 16:00 |
Presentation Mandatory |
Presentations |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Anda Gliga, Pekka Kohonen | |||||||||||||||||||||||||
| Fri 23/2 | |||||||||||||||||||||||||||||
| 09:00 - 12:00 |
Discussion Mandatory |
Discussions (in Zoom). |
4TX030 Optional location |
Hanna Karlsson Anda Roxana Gliga |
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| w9 | Mon 26/2 w9 | ||||||||||||||||||||||||||||
| 09:30 - 10:45 | Lecture | In vitro-in vivo correlations and genotoxicity testing 1 |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Hanna Karlsson | |||||||||||||||||||||||||
| 11:00 - 11:30 | Lecture | Introduction to cell cycle analysis and ELISA |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Felipe de Oliveira Galvão | |||||||||||||||||||||||||
| 13:00 - 16:00 |
Laboratory session Mandatory |
Lab week 2 See separate schedule |
4TX030 Lab at IMM |
Kristian Dreij Hanna Karlsson |
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| Tue 27/2 | |||||||||||||||||||||||||||||
| 09:00 - 16:00 |
Laboratory session Mandatory |
Lab week 2 See separate schedule |
4TX030 Lab at IMM |
Kristian Dreij Hanna Karlsson |
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| Wed 28/2 | |||||||||||||||||||||||||||||
| 09:00 - 16:00 |
Laboratory session Mandatory |
Lab week 2 See separate schedule |
4TX030 Lab at IMM |
Kristian Dreij Hanna Karlsson |
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| Thu 29/2 | |||||||||||||||||||||||||||||
| 09:00 - 16:00 |
Laboratory session Mandatory |
Lab week 2 See separate schedule |
4TX030 Lab at IMM |
Kristian Dreij Hanna Karlsson |
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| Fri 1/3 | |||||||||||||||||||||||||||||
| 09:00 - 12:00 | Seminar | In vivo-like hepatic 3D model for drug safety assessment |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Magnus Ingelman-Sundberg | |||||||||||||||||||||||||
| 13:00 - 16:00 |
Laboratory session Mandatory |
Lab week 2 See separate schedule |
4TX030 Lab at IMM |
Kristian Dreij Hanna Karlsson |
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| w10 | Mon 4/3 w10 | ||||||||||||||||||||||||||||
| 09:30 - 10:30 | Lecture | Flow cytometry analysis, oxidative stress and senescence |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Magnus Olsson | |||||||||||||||||||||||||
| 10:45 - 11:45 | Lecture | Western blot and genotoxicity testing 2 |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Felipe de Oliveira Galvão | |||||||||||||||||||||||||
| 13:00 - 16:00 |
Laboratory session Mandatory |
Lab week 3 See separate schedule |
4TX030 Lab at IMM |
Kristian Dreij Hanna Karlsson |
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| Tue 5/3 | |||||||||||||||||||||||||||||
| 09:00 - 16:00 |
Laboratory session Mandatory |
Lab week 3 See separate schedule |
4TX030 Lab at IMM |
Kristian Dreij Hanna Karlsson |
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| Wed 6/3 | |||||||||||||||||||||||||||||
| 09:00 - 16:00 |
Laboratory session Mandatory |
Lab week 3 See separate schedule |
4TX030 Lab at IMM |
Kristian Dreij Hanna Karlsson |
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| Thu 7/3 | |||||||||||||||||||||||||||||
| 09:00 - 16:00 |
Laboratory session Mandatory |
Lab week 3 See separate schedule |
4TX030 Lab at IMM |
Kristian Dreij Hanna Karlsson |
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| Fri 8/3 | |||||||||||||||||||||||||||||
| 09:00 - 12:00 | Seminar | Human Organs-on-Chips for toxicology assessment |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Anna Herland | |||||||||||||||||||||||||
| 13:00 - 16:00 |
Laboratory session Mandatory |
Lab week 3 See separate schedule |
4TX030 Lab at IMM |
Kristian Dreij Hanna Karlsson |
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| w11 | Mon 11/3 w11 | ||||||||||||||||||||||||||||
| 09:00 - 12:00 |
Seminar Mandatory |
Writing a discussion |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Anna Borgström | |||||||||||||||||||||||||
| 13:00 - 14:00 | Course council meeting |
4TX030 326, http://ki.se/medarbetare/326 |
Kristian Dreij | ||||||||||||||||||||||||||
| Tue 12/3 | |||||||||||||||||||||||||||||
| 09:00 - 15:00 |
Workshop Mandatory |
Peer-review of lab reports (In Zoom) |
4TX030 Optional location |
Anna Borgström | |||||||||||||||||||||||||
| Wed 13/3 | |||||||||||||||||||||||||||||
| 09:00 - 12:00 | Laboratory session | Demo-lab: Comet assay |
4TX030 Lab at IMM |
Hanna Karlsson | |||||||||||||||||||||||||
| Thu 14/3 | |||||||||||||||||||||||||||||
| 09:00 - 17:00 | Self-study | Preparation for JC#2 |
4TX030 Optional location |
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| Fri 15/3 | |||||||||||||||||||||||||||||
| 09:00 - 12:00 |
Presentation Mandatory |
Presentation of Journal Club 2. Groups 1, 3, 5, 7, 9. |
4TX030 221, http://ki.se/medarbetare/221 |
Kristian Dreij | |||||||||||||||||||||||||
| 13:00 - 16:00 |
Presentation Mandatory |
Presentation of Journal Club 2. Groups 2, 4, 6, 8, 10. |
4TX030 221, http://ki.se/medarbetare/221 |
Kristian Dreij | |||||||||||||||||||||||||
| w12 | Mon 18/3 w12 | ||||||||||||||||||||||||||||
| 09:00 - 12:00 |
Workshop Mandatory |
Toxicogenomics and benchmark dose modelling workshop |
4TX030 Ada Lovelace, https://medarbetare.ki.se/ada-lovelace |
Pekka Kohonen Anda Roxana Gliga |
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| 13:00 - 16:00 |
Workshop Mandatory |
Toxicogenomics and benchmark dose modelling workshop |
4TX030 Ada Lovelace, https://medarbetare.ki.se/ada-lovelace |
Pekka Kohonen Anda Roxana Gliga |
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| Tue 19/3 | |||||||||||||||||||||||||||||
| 09:45 - 11:30 | Laboratory session | Demo advanced light microscopy SciLifeLab, Tomtebodavägen 23 |
4TX030 Lab at IMM https://www.scilifelab.se/units/integrated-microscopy-technologies/ |
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| Wed 20/3 | |||||||||||||||||||||||||||||
| 09:00 - 16:00 | Self-study | Preparation of presentation |
4TX030 Optional location |
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| Thu 21/3 | |||||||||||||||||||||||||||||
| 09:00 - 16:00 | Self-study | Preparation of presentation |
4TX030 Optional location |
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| Fri 22/3 | |||||||||||||||||||||||||||||
| 09:15 - 14:45 |
Presentation Mandatory |
Lab report presentations, see detailed schedule in Canvas. |
4TX030 221, http://ki.se/medarbetare/221 |
Kristian Dreij Anda Roxana Gliga |
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| w13 | Mon 25/3 w13 | ||||||||||||||||||||||||||||
| 09:00 - 09:30 |
Lecture Mandatory |
Intro to workshop and to zebrafish as experimental model in toxicology research |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Emma Wincent | |||||||||||||||||||||||||
| 09:45 - 10:30 | Lecture | Zebrafish embryo as model to study effects of metals of on growth and development |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Maria Gonzalez | |||||||||||||||||||||||||
| 10:45 - 11:30 | Lecture | The role of AHR on tissue repair – zebrafish neuromast injury as an example |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Lydia Gugescu | |||||||||||||||||||||||||
| 12:30 - 17:00 |
Laboratory session Mandatory |
Group 1-5, self studies. Group 6-10, lab. See detailed schedule. |
4TX030 Lab at IMM |
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| Tue 26/3 | |||||||||||||||||||||||||||||
| 09:00 - 09:45 |
Lecture Mandatory |
The zebrafish model in basic and preclinical research |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Lars Bräutigam | |||||||||||||||||||||||||
| 10:00 - 16:30 |
Laboratory session Mandatory |
Core facility visit, labs, self studies. See detailed schedule. |
4TX030 Lab at IMM |
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| Wed 27/3 | |||||||||||||||||||||||||||||
| 09:00 - 10:15 | Self-study |
4TX030 Optional location |
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| 10:30 - 11:45 |
Lecture Mandatory |
Kinetic consideration of mixture exposure |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Dennis Lindqvist | |||||||||||||||||||||||||
| 13:00 - 14:15 |
Lecture Mandatory |
Studies on AHR-mediated developmental toxicity |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Emma Wincent | |||||||||||||||||||||||||
| 14:30 - 16:00 |
Lecture Mandatory |
TBA |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
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| Thu 28/3 | |||||||||||||||||||||||||||||
| 09:30 - 11:00 |
Discussion Mandatory |
Discussions on lab exercise |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Emma Wincent | |||||||||||||||||||||||||
| Fri 29/3 | |||||||||||||||||||||||||||||
| 09:00 - 17:00 | Self-study | Easter |
4TX030 Optional location |
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| w14 | Mon 1/4 w14 | ||||||||||||||||||||||||||||
| 09:00 - 17:00 | Self-study | Easter |
4TX030 Optional location |
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| Tue 2/4 | |||||||||||||||||||||||||||||
| 09:00 - 17:00 | Self-study | Easter |
4TX030 Optional location |
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| Wed 3/4 | |||||||||||||||||||||||||||||
| 09:00 - 17:00 | Self-study | Easter |
4TX030 Optional location |
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| Thu 4/4 | |||||||||||||||||||||||||||||
| 09:00 - 17:00 | Self-study | Easter. Deadline lab report 17.00! |
4TX030 Optional location |
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| Fri 5/4 | |||||||||||||||||||||||||||||
| 10:00 - 12:00 |
Lecture Mandatory |
Introduction to Alternative methods plus assignment (In Zoom) |
4TX030 Digital teaching |
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| 12:00 - 17:00 | Self-study | Literature assignment |
4TX030 Optional location |
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| w15 | Mon 8/4 w15 | ||||||||||||||||||||||||||||
| 09:00 - 09:45 | Lecture | Alternative methods and some regulatory considerations: examples from the world of medical devices |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Charlotte Nilsson | |||||||||||||||||||||||||
| 10:00 - 10:45 | Lecture | A NAM for assessing carcinogenic potency of complex mixtures |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Kristian Dreíj | |||||||||||||||||||||||||
| 11:00 - 11:45 | Lecture | IATA in practice with focus on neurotoxicity adverse outcome pathways |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Anna Forsby | |||||||||||||||||||||||||
| 12:00 - 17:00 | Self-study | Literature assignment |
4TX030 Optional location |
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| Tue 9/4 | |||||||||||||||||||||||||||||
| 09:00 - 09:45 | Lecture | In vitro models for endocrine disruption-induced developmental neurotoxicity |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Joëlle Rüegg | |||||||||||||||||||||||||
| 10:00 - 10:45 | Lecture | The PEPPER platform - Pre-validation of characterization methods for endocrine disruptors |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Diana Lupu | |||||||||||||||||||||||||
| 11:00 - 11:45 | Lecture | Pulmonary disease modelling and toxicity screening - alternative methods aligning to the 3R concept |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Anna-Karin Larsson Callerfelt | |||||||||||||||||||||||||
| 12:00 - 17:00 | Self-study | Literature assignment |
4TX030 Optional location |
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| Wed 10/4 | |||||||||||||||||||||||||||||
| 09:00 - 10:30 |
Discussion Mandatory |
Group discussions in vitro vs in vivo |
4TX030 Optional location |
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| 10:30 - 11:30 |
Discussion Mandatory |
QA in Zoom |
4TX030 Digital teaching |
Kristian Dreij, Lars Wiklund | |||||||||||||||||||||||||
| 12:00 - 17:00 | Self-study | Literature assignment |
4TX030 Optional location |
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| Thu 11/4 | |||||||||||||||||||||||||||||
| 09:00 - 12:00 |
Presentation Mandatory |
Presentations of literature assignment. |
4TX030 212, https://medarbetare.ki.se/212 214, https://medarbetare.ki.se/214 202, https://staff.ki.se/202 210, https://medarbetare.ki.se/campus-hus-och-miljoer/bokningsbara-lokaler/bokningsbara-lokaler-pa-campus-solna/210 |
Lars Wiklund Kristian Dreij Hanna Karlsson Anna Beronius Johanna Zilliacus Annika Hanberg Elin Törnqvist Charlotte Nilsson |
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| 13:00 - 15:00 |
Lecture Mandatory |
Concluding seminar on NAMs |
4TX030 Gunnar Höglund, https://medarbetare.ki.se/larosal-gunnar-hoglund |
Ian Cotgreave | |||||||||||||||||||||||||
| Fri 12/4 | |||||||||||||||||||||||||||||
| 09:00 - 17:00 | Self-study |
4TX030 Optional location |
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| w16 | Mon 15/4 w16 | ||||||||||||||||||||||||||||
| 09:00 - 17:00 | Self-study |
4TX030 Optional location |
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| Tue 16/4 | |||||||||||||||||||||||||||||
| 09:00 - 14:00 | Self-study |
4TX030 Optional location |
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| 14:15 - 18:15 | Examination | Digital tentamen |
4TX030 Skrivsal Widerströmska, https://medarbetare.ki.se/skrivsal-widerstromska |
Kristian Dreij | exam.timeedit.com | ||||||||||||||||||||||||